The Gilk Lab
Coxiella burnetii sterol modifying enzyme Stmp1 regulates cholesterol in in the intracellular niche. Clemente TM, Ratnayake R, Samanta D, Augusto L, Beare PA, Heinzen RA, and SD Gilk. 2022, mBio, doi.org/10.1128/mbio.03073-21.
Cholesterol and Pathogens. TM Clemente and SD Gilk. In the book Cholesterol, edited by Anna Buliya and Alex Dopico. In press.
Lipid Hijacking: a unifying theme in vector-borne diseases. AJ O'Neal, LR Butler, A Rolandelli, SD Gilk, and JHF Pedra. 2020. eLife, Oct 29. doi: 10.7554/eLife.61675
Coxiella burnetii Type 4B Secretion System-dependent manipulation of endolysosomal maturation is required for bacterial growth. Samanta D, Clemente TM, Schuler BE, and SD Gilk. 2019. PLoS Pathogens, Dec 23; 15(2).doi: 0.1371/journal.ppat.1007855
Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacteria. Cockburn C, Green R, Damle S, Martin R, Ghahrai N, Colonne P, Fullerton M, Conrad D, Chalfant C, Voth D, Rucks E, Gilk SD, and J Carlyon. 2019. Life Sciences Alliance, Mar 22;2(2). doi: 10.26508/lsa.201800292.
Coxiella burnett blocks intracellular IL-17 signaling in macrophages. Clemente TM, Mulye M, Justis AV, Nallandhighal S, Tran TM, and SD Gilk. 2018. Infection and Immunity. July 30. pii: IAI.00532-18. doi: 10.1128/IAI.00532-18
Altering lipid droplet homeostasis affects Coxiella burnetii growth. Mulye M, Zapata B, and SD Gilk. 2018. PloS One. Feb 1;13(2):e0192215. doi: 10.1371/journal.pone.0192215. eCollection 2018.
Measuring pH of the Coxiella burnetii parasitophorous vacuole. D Samanta and SD Gilk. 2017. Current Protocols in Microbiology,Nov 9; 47: 9;47:6C.3.1-6C.3.11. doi: 10.1002/cpmc.38.
Quantitative dextran trafficking to the Coxiella burnetii vacuole. S Winfree and SD Gilk. 2017. Current Protocols in Microbiology, Aug 11; 46:46:6C.2.1-6C.2.12. doi: 10.1002/cpmc.34.
Manipulation of host cholesterol by obligate intracellular bacteria. Samanta D, Mulye M, Clemente TM, Justis AV and SD Gilk. 2017. Frontiers in Cellular and Infection Microbiology, May 5; 7:165.doi: 10.3389/fcimb.2017.00165.
Elevated cholesterol in the Coxiella burnetii intracellular niche is bacteriolytic. Mulye M, Samanta D, Heinzen RA, and SD Gilk. 2017. mBio.
Interactions between the Coxiella burnetii parasitophorous vacuole and the endoplasmic reticulum involve the host protein ORP1L. Justis AV, Hansen B, Beare PA, King KB, Heinzen RA, and SD Gilk. 2017. Cellular Microbiology.
Altering LD homeostasis in alveolar macrophages affects Coxiella burnetii intracellular growth. Mulye M, Zapata B, and SD Gilk. 2017. BioRxv.
Bacterial colonization of host cells in the absence of cholesterol. Gilk SD, Cockrell DA, Luterbach C, Hansen B, Knodler L, Steele-Mortimer O, and RA Heinzen. 2013. PLoS Pathogens.
Two systems for targeted gene deletion in Coxiella burnetii. Beare PA, Larson CL, Gilk SD, and RA Heinzen. 2012. Appl Environ Microbiol.
The Dot/Icm type IVB secretion system requirements for Coxiella burnetii growth in human macrophages. Beare PA, Gilk SD, Larson CL, Hill J, Stead CM, Howe D, Omsland A, Cockrell DC, Voth DE, and RA Heinzen. 2011. mBio.